Effect of the airway obstruction severity on the survival of patients with non-small cell lung cancer after surgical treatment
https://doi.org/10.51922/2616-633X.2022.6.1.1519
Abstract
Lung cancer is a medical and social problem. Pulmonary function parameters that were obtained from spirometry had a statistically significant influence on the overall survival of patients with non-small cell lung cancer.
Aim of study: to establish the role of indicators characterizing the severity of airway obstruction in patients with non-small cell lung cancer stages I-III and to assess its effect on the survival of patients after surgical treatment.
Material of study: the study included 303 patients with non-small cell lung cancer (NSCLC) in stages I-III, who had been receiving treatment at the Minsk City Clinical Cancer Center from 2000 to 2018, the patients’ indicators of respiratory failure being determined and long-term results of treatment being monitored.
Results and conclusion: after surgical treatment, the 5-year overall survival (OS) rate of patients with NSCLC in the absence of bronchial obstruction was 42.4%, and in case of bronchial obstruction of the IIIrd-IVth degree, the 5-year OS was 14.8% (p = 0.006).
About the Authors
M. Shapetska
Belarusian State Medical University
Belarus
Belarus
L. Mirilenko
State Institution “N. N. Alexandrov National Cancer Center of Belarus”
Belarus
Belarus
A. Prokharau
Belarusian State Medical University
Belarus
Belarus
References
1. Zhukov N.V. Angiogenez kak faktor metastazirovaniya i mishen’ dlya protivoopuholevoj terapii (obzor literatury) [Angiogenesis as a metastasizing factor and a target for antitumor therapy (review of literature)]. Voprosy gematologii/onkologii i immunopatologii v pediatrii, 2009, vol. 8, no. 4, pp. 27–33. (in Russian)
2. Andreenko E.Yu., Yavelov I.S., Loukianov M.M., Vernohaeva A.N., Drapkina O.M., Boytsov S.A. Ishemicheskaya bolezn’ serdca u lic molodogo vozrasta: rasprostranennost’ i serdechno-sosudistye faktory riska [Ischemic heart disease in subjects of young age: current state of the problem. prevalence and cardio-vascular risk factors]. Kardiologiya, 2018, vol. 58, no. 10, pp. 53–58. doi: 10.18087/cardio.2018.10.10184. (in Russian)
3. Goldstraw P., Crowley J., Chansky K., Giroux D.J., Groome P.A., Rami-Porta R., Postmus P.E., Rusch V., Sobin L. The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours. J of Thorac Oncol, 2007, vol. 2, no. 8, pp. 706–714. doi: 10.1097/JTO.0b013e31812f3c1a.
4. Barahovskaya T.V. Hronicheskaya obstruktivnaya bolezn’ legkih [Chronic obstructive pulmonary disease] : ucheb. posobie. Irkutsk, 2015. 66 s. (in Russian)
5. Vogelmeier C.F., Criner G.J., Martinez F.J., Anzueto A., Barnes P.J., Bourbeau J., Celli B.R., Chen R., Decramer M., Fabbri L.M., Frith P., Halpin D.M., López Varela M.V., Nishimura M., Roche N., Rodriguez-Roisin R., Sin D.D., Singh D., Stockley R., Vestbo J., Wedzicha J.A., Agustí A. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report. GOLD executive summary. Am J Respir Crit Care Med, 2017, vol. 195, no. 5, pp. 557–582.
6. Nazarova L.S., Zavjalov A.A., Tuzikov S.A., Volkova L.I. Ocenka osnovnyh pokazatelej funkcii vneshnego dyhaniya u bol’nyh rakom legkogo na etapah kombinirovannogo lecheniya [Assessment of external respiration function in lung cancer patients]. Sibirskij onkologicheskij zhurnal, 2007, no. 3, pp. 31–38. (in Russian)
7. Donington J.S., Kim Y.T., Tong B., Moreira A.L., Bessich J., Weiss K.D., Colson Y.L., Wigle D., Osarogiagbon R.U., Zweig J., Wakelee H., Blasberg J. Daly M., Backhus L., Van Schil P. Progress in the management of early-stage non-small cell lung cancer in 2017. J of Thorac Oncol, 2018, vol. 13, no. 6, pp. 767–778. doi: 10.1016/j.jtho.2018.04.002.
8. Algoritmy diagnostiki i lecheniya zlokachestvennyh novoobrazovanij [Algorithms for the diagnosis and treatment of malignant neoplasms] : sb. nauch. st. / M-vo zdravoohraneniya Resp. Belarus’, Resp. nauch.-prakt. centr onkologii i med. radiologii im. N.N. Aleksandrova ; pod red. O.G. Sukonko, S.A. Krasnogo. Minsk, 2012. 508 s. (in Russian)
9. Ob utverzhdenii klinicheskogo protokola «Algoritmy` diagnostiki i lecheniya zlokachestvenny`x novoobrazovanij» [On approval of the clinical protocol “Algorithms for the diagnosis and treatment of malignant neoplasms”] : postanovlenie M-va zdravooxraneniya Resp. Belarus`, 6 iyulya 2018 g., № 60. Konsul`tantPlyus. Belarus` / OOO «YurSpektr», Nacz. centr pravovoj inform. Resp. Belarus`. Minsk, 2022. (in Russian)
10. Zhang H, Ni J, Cheng Q. Ventilation in patients with stage IIIB or above lung cancer. Ann Transl Med. 2021 Nov;9(22):1647. doi: 10.21037/atm-21-2203.
Review
For citations:
Shapetska M., Mirilenko L., Prokharau A. Effect of the airway obstruction severity on the survival of patients with non-small cell lung cancer after surgical treatment. Emergency Cardiology and Cardiovascular Risks journal. 2022;6(1):1519-1524. (In Russ.) https://doi.org/10.51922/2616-633X.2022.6.1.1519
Views:
5
Email this article 