Перспективы атомно-силовой микроскопии в изучении патологических процессов у пациентов кардиологического профиля

Во всем мире вопросу изучения фундаментальных клеточных процессов посвящены многочисленные изыскания. Развитие новых методов исследований с высокой разрешающей способностью сделало возможным изучение патологических процессов на микро- и наноуровне. Атомно-силовая микроскопия – один из перспективных методов получения качественной и количественной информации о патологических состояниях, основанный на анализе топографии поверхности (размеров, шероховатости) и локальных механических свойств (модуля упругости, силы адгезии, трибологических характеристик) структурных элементов клеток и тканей. В статье кратко описан принцип работы метода и возможности его применения в различных областях медицины (терапии, онкологии, офтальмологии, трансфузиологии, стоматологии и др.). Подробно представлена роль форменных элементов крови (эритроциты, тромбоциты) в патогенезе заболеваний у пациентов кардиологического профиля. Рассмотрены возможности метода в изучении характеристик атеросклеротической бляшки в коронарных артериях на разных этапах атерогенеза.

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