Intestinal microflora of normotensive patients with visceral obesity

Weobtained changed readings in the quantitative composition of certain representatives of the intestinal microflora characteristic of normotensive patients with visceral obesity in comparison with normotensive patients without visceral obesity. They included a decreased pool of commensal bacteria Faecalibacterium spp. (10.51 ± 1.13 vs. 9.5 ± 1.14, p = 0.020), Lactobacillus spp. (9.17 ± 1.74 vs. 8.00 ± 2.52, p = 0.025), Bacteroides spp. (9.02 ± 0.76 vs. 8.46 ± 0.47, p = 0.027), Fusobacterium spp. (13.4 ± 1.01 vs. 12.03 ± 0.92, p < 0,001), Bifidobacterium spp. (7.31 ± 1.16 vs. 5.95 ± 1.82, p = 0.028) respectively. Quantitative content of representatives of opportunistic intestinal microflora Streprococcus spp. (6.31 ± 0.79 vs. 5.87 ± 0.78, p = 0.032) and Staphylococcus spp. (6.67 ± 1.23 vs. 5.98 ± 0.98, p = 0.036) was increased in patients with visceral obesity compared to the group of patients without visceral obesity.

1. Obesity and overweight. Bulletin World Health Organization. 2021.

2. Vasyukova O.V. Federal clinical guidelines for the diagnosis and treatment of obesity in children and adolescents. M.: Rossijskaya associaciya endokrinologov, 2013, pp. 5-8. (in Russian).

3. Borga M., West J., Bell J.D., et al. Advanced body composition assessment: From body mass index to body composition profiling. J Investig Med, 2018, vol. 66 (5), pp. 1-9. doi: 10.1136/jim-2018-000722.

4. Simoni P., Guglielmi R., Aparisi Gomez M.P. Imaging of body composition in children. Quant Imaging Med Surg, 2020, vol. 10 (8), pp. 1661-1671. doi: 10.21037/qims.2020.04.06.

5. Kotrova A.D., Shishkin A. N., Ermolenko E. I., Sarajkina D.A., et al. Gut microbiota in arterial hypertension. Arterialnaya gipertenziya, 2020, vol. 26, pp. 620-628. (in Russian).

6. Chervinec V. M., Chervinec Y.V., Belyaeva E.A., Petrova O.A., et al. Metabolic activity of highly antagonistic lactobacilli strains from healthy humans. Zhurnal mikrobiologii, epidemiologii i immunobiologii, 2018, vol. 95 (4), pp. 11-17. (in Russian).

7. Chen L., Luo Y., Wang H., et al. Effects of glucose and starch on lactate roduction by newly isolated streptococcus bovis S1 from saanen goats. Appl Environ Microbiol. 2016, vol. 82 (19), pp. 5982–5989. doi: 10.1128/AEM.01994-16.

8. Shariq O.A., McKenzie T.J. Obesity-related hypertension: a review of pathophysiology, management, and the role of metabolic surgery. Gland Surg, 2020, vol. 9 (1), pp. 80-93. doi: 10.21037/gs.2019.12.03.

9. Cuevas-Sierra A., Ramos-Lopez O., Riezu-Boj J.I., Milagro F.I., Martinez J.A. Diet, Gut Microbiota, and Obesity: Links with Host Genetics and Epigenetics and Potential Applications. Adv Nutr, 2019, vol. 10 (suppl_1), pp. S17-S30. doi: 10.1093/advances/nmy078.

10. Chervinec V.M., Chervinec Y.V., Serova N.E., et al. Microbiome of the oral cavity and intestine in patients with arterial hypertension. Bulletin of the Orenburg Scientific Center of the Ural Branch of the Russian Academy of Sciences, 2019, vol. 3, pp. 27. (in Russian).

11. .Chambers E.S., Preston T., Frost G., Morrison D.J. Role of gut microbiota-generated short-chain fatty acids in metabolic and cardiovascular health. Curr Nutr Rep, 2018, vol. 7 (4), pp. 198-206. doi: 10.1007/s13668-018-0248-8.

12. .Kim S., Goel R., Kumar A. et al. Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure. Clin. Sci. (Lond), 2018, vol. 132 (6), p. 701-718. doi: 10.1042/CS20180087.