Practical applications of hemoglobin-based oxygen carriers in organ transplantation
https://doi.org/10.51922/2616-633X.2024.8.1.2181
Abstract
In recent years, much attention has been paid to the excellent oxygen transport properties of Hemoglobin-based oxygen carriers (HBOCs), which deliver oxygen to organs and tissues via arterial blood by binding oxygen and carbon dioxide via venous blood back to the lungs for respiratory elimination from the body. Studies have shown that HBOCs, which are characterized by low immunogenicity, little risk of hemolytic reaction, low viscosity, and enhanced diffusive oxygen transport, can show excellent results in clinical applications in the field of organ transplantation. Early HBOCs generations had a short intravascular circulation life-time, could cause vasospastic and toxic side effects induced by free hemoglobin circulation. Polymerization of hemoglobin molecules significantly increased the size of acellular hemoglobin, thus minimizing the extravasation and prolonging their half-life in intravascular circulation, and was considered to be the key factor in mitigating the vasoconstriction effects.
The aim of this paper is to provide an in-depth review of the current status of research and application of HBOCs in organ transplantation, as well as to look forward to their future application in this field.
About the Authors
Qinqi Wang
School of Chemical and Environmental Engineering, Changchun University of Science and Technology; Redpharm (Beijing) Biotech Limited
China
China
Qinqi Wang
130022; Changchun; 100176; Beijing
L. Shestakova
Belarusian Republican Scientific and Practical Center of Cardiology
Belarus
Belarus
Liana Shestakova
220036; 110 B R.Luxemburg Str.; Minsk
I. Kolesnik
Institute of Physical Organic Chemistry of National Academy of Sciences of Belarus
Belarus
Belarus
Irina Kolesnik
220072; 13 Surganov Str.; Minsk
Jianxun Ding
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
China
China
Jianxun Ding
130022; Changchun
Tianmeng Sun
Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin University
China
China
Tianmeng Sun
130061; Changchun
Wenliang Li
School of Chemical and Environmental Engineering, Changchun University of Science and Technology; Redpharm (Beijing) Biotech Limited
China
China
Wenliang Li
130022; Changchun; 100176; Beijing
You. Ostrovsky
Belarusian Republican Scientific and Practical Center of Cardiology
Belarus
Belarus
Youry Ostrovsky
220036; 110 B R.Luxemburg Str.; Minsk
Yu. Aliakseyeu
Belarusian “Innovative International Center for Scientific, Educational and Commercial Cooperation “Delo”
Belarus
Belarus
Yury Aliakseyeu
Minsk
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Review
For citations:
Wang Q., Shestakova L., Kolesnik I., Ding J., Sun T., Li W., Ostrovsky Y., Aliakseyeu Yu. Practical applications of hemoglobin-based oxygen carriers in organ transplantation. Emergency Cardiology and Cardiovascular Risks journal. 2024;8(1):2181-2186. https://doi.org/10.51922/2616-633X.2024.8.1.2181
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